开设化学课的目的是使学生对化学概念行成初步的认识和了解。化学不是一门纯理论性的科目，老师鼓励学生在其指导下进行试验，以此来巩固他们所学到的知识并希望学生将其运用到生活中。多数高中都将化学课作为GCSE结束前的核心科目。
| 排名 | 校名 | 所在地 | 考生人数 | A级生比例 |
| 1 | Wycombe Abbey School | High Wycombe | 18 | 94.4% |
| 2 | Saint Paul's School | London | 51 | 87.7% |
| 3 | Tonbridge School | Tonbridge | 34 | 85.4% |
| 4 | Westminster School | London | 44 | 84.1% |
| 5 | Headington School | Oxford | 38 | 80.9% |
| 6 | Winchester College | Winchester | 62 | 79.5% |
| 7 | Cheltenham Ladies' College(The) | Cheltenham | 32 | 79.4% |
| 8 | Saint Swithun's School | Winchester | 26 | 76.6% |
| 9 | Concord College | Shrewsbury | 55 | 76.2% |
| 10 | Charterhouse | Godaiming | 45 | 75.4% |
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